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Prolonged QT Interval in Neurodevelopmental Rat Model of Schizophrenia

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F16%3APU120838" target="_blank" >RIV/00216305:26220/16:PU120838 - isvavai.cz</a>

  • Result on the web

    <a href="https://ieeexplore.ieee.org/document/7868926" target="_blank" >https://ieeexplore.ieee.org/document/7868926</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Prolonged QT Interval in Neurodevelopmental Rat Model of Schizophrenia

  • Original language description

    QT prolongation is an independent risk factor for development of ventricular arrhythmias and eventually sudden cardiac death. It is common side effect of various medications, including antipsychotics. It was reported that schizophrenic patients treated with antipsychotics (e.g. haloperidol, olanzapine) manifested QT prolongation. Also, drug-free schizophrenic patients have increased QT interval compared to healthy controls. Possible mechanisms of QT prolongation connected with schizophrenia are still unclear. The present study on isolated hearts clearly shows that rats with schizophrenia-like phenotype manifest significantly lengthened QT interval as compared to controls. This difference was further increased after acute haloperidol administration. These data indicate that methylazoxymethanol acetate rat model of schizophrenia may be applicable tool for studying of connection between schizophrenia and QT prolongation.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

  • OECD FORD branch

    20601 - Medical engineering

Result continuities

  • Project

    <a href="/en/project/GAP102%2F12%2F2034" target="_blank" >GAP102/12/2034: Analysis of Relationship between Electrical Activity and Blood Flow at the Heart Ventricles</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Computing in Cardiology Conference

  • ISBN

    978-1-5090-0895-7

  • ISSN

  • e-ISSN

  • Number of pages

    4

  • Pages from-to

    1049-1052

  • Publisher name

    Neuveden

  • Place of publication

    Neuveden

  • Event location

    Vancouver

  • Event date

    Sep 11, 2016

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article

    000405710400263