Haloperidol affects coupling between QT and RR intervals in guinea pig isolated heart

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F19%3A00508002" target="_blank" >RIV/68081731:_____/19:00508002 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/19:00109024 RIV/00216305:26220/19:PU134871 RIV/00159816:_____/19:00071099

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1347861318302056?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1347861318302056?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jphs.2018.11.004" target="_blank" >10.1016/j.jphs.2018.11.004</a>

Result language

angličtina

Original language name

Haloperidol affects coupling between QT and RR intervals in guinea pig isolated heart

Original language description

Prolonged QT interval is an independent risk factor for development of ventricular arrhythmias. Haloperidol is one of the drugs inducing QT prolongation. Previous studies showed that haloperidol affects not only QT duration but also heart rate (RR interval). The present work focused on relationship between QT and RR and its changes under acute and chronic haloperidol administration. The study included 14 male guinea pigs divided into control and haloperidol-treated group. After 21-days administration of haloperidol or vehiculum, electrograms in isolated hearts were recorded. QT/RR and dQT/dRR coupling were calculated. Chronic haloperidol administration significantly decreases the coupling between QT and RR. Acute haloperidol exposure significantly decreases the dQT/dRR coupling in both treated and untreated guinea pig hearts. Flatter QT/RR relationship reveals a lack of QT adaptation to increased heart rate. It should be emphasized that in such situation ECG recording will not show significant QT prolongation evaluated according to clinical rules. However, if QT interval does not adapt to increased heart rate sufficiently, the risk of ventricular arrhythmias may be increased despite practically normal QT interval length. The results are supported by findings in biochemical analyses, which proved eligibility of the used model. (c) 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20601 - Medical engineering

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Pharmacological Sciences

ISSN

1347-8613

e-ISSN

—

Volume of the periodical

139

Issue of the periodical within the volume

JAN

Country of publishing house

JP - JAPAN

Number of pages

6

Pages from-to

23-28

UT code for WoS article

000454120200004

EID of the result in the Scopus database

2-s2.0-85057632115