Comparison of the ATH and 2CXM models using low- and high-molecular-weight contrast agents in DCE-MRI

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F16%3APU125927" target="_blank" >RIV/00216305:26220/16:PU125927 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s10334-016-0571-2" target="_blank" >http://dx.doi.org/10.1007/s10334-016-0571-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10334-016-0571-2" target="_blank" >10.1007/s10334-016-0571-2</a>

Result language
angličtina
Original language name
Comparison of the ATH and 2CXM models using low- and high-molecular-weight contrast agents in DCE-MRI
Original language description
In DCE-MRI, tissue contrast-agent (CA) concentration curves are modeled as a convolution of the arterial input function (AIF) and the impulse residue function (IRF). The 2CXM and ATH models are the most widely used advanced IRF models that provide separate estimates of blood flow, Fb, and permeability-surface area product, PS, contrary to the commonly applied Tofts models. No consensus exists on which advanced pharmacokinetic model is better. Simulation-based and blind-deconvolution-based preclinical model comparisons are published. This contribution presents a new model-evaluation method based on high- and low-molecular weight (MW) contrast-agents administered within one examination. Some perfusion parameters are expected to be MW-independent (namely Fb and blood volume—vb), while PS should decrease with increasing MW.
Czech name
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Czech description
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Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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