Advanced Pharmacokinetic Modeling in Small-Animal Compressed-Sensing DCE-MRI

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F19%3APU132776" target="_blank" >RIV/00216305:26220/19:PU132776 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Advanced Pharmacokinetic Modeling in Small-Animal Compressed-Sensing DCE-MRI
Original language description
To overcome the physical limits of the achievable spatial and temporal resolution in Dynamic Contrast-Enhanced (DCE) MRI, compressed-sensing (CS) techniques have been proposed [1]. So far, CS has been combined only with simpler pharmacokinetic (PK) models (e.g. generalized kinetic model [2]), which do not provide estimates of blood flow, Fb, and permeability-surface area product, PS. To the authors' knowledge, no CS DCE has been shown for advanced PK models, i.e. models providing also estimates of Fb and PS. This is probably because the requirements of these models on temporal resolution and the signal-to- noise ratio (SNR) are much higher than for simple PK models. We use an advanced PK model (adiabatic approximation of the tissue homogeneity model - ATH) in combination with CS, based on a 3D radial golden-angle (GA) stack-of-stars (SOS) acquisition [3] and the L+S reconstruction [4].
Czech name
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Czech description
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Project
<a href="/en/project/GA16-13830S" target="_blank" >GA16-13830S: Magnetic resonance perfusion imaging using compressed sensing</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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