Epicardial delivery of diversified pulsed field potentials in animal model

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F19%3APU132738" target="_blank" >RIV/00216305:26220/19:PU132738 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Epicardial delivery of diversified pulsed field potentials in animal model
Original language description
Ablation of arrhythmias is based on thermal energy methods, radiofrequency and cryoablation. Despite high success rate, thermal character limits lesion formation control and may affect esophagus, phrenic nerve, and lungs. Non thermal irreversible electroporation (IRE) is inducing apoptotic cell death, is tissue-specific and effective. The comparison between AC/DC energy sources has not been systematically approached, clinically relevant parameters are yet to be validated. Methods: 12 farm pigs (female, 6m old, 45-55kg) underwent thoracotomy and epicardial IRE shock delivery. Square DC/AC pulse generators were connected to planar stainless-steel electrode (6x6mm) in a suction cup for tissue adherence, versus reference patch on the animal back (ca. 40cm from heart). High voltage AC/DC pulses (10 and 2 animals, 100 µs, 60 pulses, each set of 400, 600 and 800 V) were delivered in myorelaxation, at target frequency 80/min. in 3x3 grid application on left ventricle and 2*2 grid on left atrium, marked by sur
Czech name
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Czech description
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Project
<a href="/en/project/LO1210" target="_blank" >LO1210: Energy for Sustainable Development</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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