Alternate current high voltage pulses induce apoptotic death in myocardium by irreversible electroporation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F19%3APU133980" target="_blank" >RIV/00216305:26220/19:PU133980 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Alternate current high voltage pulses induce apoptotic death in myocardium by irreversible electroporation
Original language description
Background: Irreversible electroporation (IRE) holds the promise to revolutionize catheter ablation of arrhythmia, overcoming the limits of thermal-based therapies. A careful combination of pulse parameters, safety conditions and knowledge of cell death mechanism must be pursued to maximize the benefits of the envisioned therapies. Aims: Identify a combination of parameters to induce complete local cell death. Prove the feasibility, efficacy and safety of AC-IRE ablation. Characterize the cellular and tissue damages induced by the AC-IRE application. Methods: Three study models are employed. In the first one, a cuvette-based system is used to calibrate the optimal pair of electric field-number of pulses to induce complete cell death. In the second one, a microelectrode array (MEA) system is used in combination with calcium imaging to identify electrical and ionic changes in cardiac cells affected by the identified pulse combination. In the third one, a swine model was used to study underwent AC-IRE ablation in left atrium (pulmonary vein ostia, chamber walls) and intraventricular septum.
Czech name
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Czech description
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Project
<a href="/en/project/LO1210" target="_blank" >LO1210: Energy for Sustainable Development</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
3rd World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine, and Food and Environmental Technologies
ISBN
978-2-913923-38-6
ISSN
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e-ISSN
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Number of pages
1
Pages from-to
1-1
Publisher name
Neuveden
Place of publication
Neuveden
Event location
Toulouse
Event date
Sep 3, 2019
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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