Responsive therapy with multi-stage detection of seizures in human epilepsy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F20%3APU138067" target="_blank" >RIV/00216305:26220/20:PU138067 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Responsive therapy with multi-stage detection of seizures in human epilepsy
Original language description
Rationale: Electrical brain stimulation (EBS) has been used successfully for treatment of drug resistant temporal lobe epilepsy. In particular, responsive neural stimulation (RNS) is an approach that delivers a brief electrical stimulation burst when epileptiform activity or seizure is detected. The RNS therapy is designed to be delivered to the brain region generating seizures. In the future it might be beneficial to track whether the initial stimulation therapy terminated the seizure, and in cases where stimulation has not stopped the seizure the therapy can be switched to a different network target. In that case, cascade detectors need to be enabled within the implanted neural stimulator (INS). We modelled, implemented, and investigated a multi-stage therapy control approach embedded in an INS to stimulate multiple brain targets with different stimulation settings. Methods: We created a database of intracranially recorded hippocampal seizures and interictal periods in patients undergoing surgical
Czech name
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Czech description
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Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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