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Adaptive Neurostimulation with Multi-Stage Control Loop: Application to Drug Resistant Epilepsy

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F21%3APU142127" target="_blank" >RIV/00216305:26220/21:PU142127 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Adaptive Neurostimulation with Multi-Stage Control Loop: Application to Drug Resistant Epilepsy

  • Original language description

    Responsive neural stimulation (RNS) delivers electrical stimulation in a brain region in response to brain activity to treat neurological disorders. RNS directed at seizures and abnormal epileptiform activity proved to be successful in reducing seizures in drug resistant epilepsy, but efficacy optimization can be slow. There is ongoing interest in systems where stimulation paradigms and network targets are optimized adaptatively over time. Here we present a system where a cascade of detectors in implanted neural sensing and stimulation (INSS) device and a handheld device enabling machine learning seizure detection algorithms to adaptively control stimulation parameters and brain targets. We developed a system for multi-stage control over adaptive neurostimulation paradigms. The system utilizes an INSS with continuous real-time intracranial EEG (iEEG) recording and bi-directional communication with a handheld for off-device programmable control. The adaptive RNS settings on the INSS device engage multi

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

  • OECD FORD branch

    20601 - Medical engineering

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů