Adaptive Neurostimulation with Multi-Stage Control Loop: Application to Drug Resistant Epilepsy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F21%3APU142127" target="_blank" >RIV/00216305:26220/21:PU142127 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Adaptive Neurostimulation with Multi-Stage Control Loop: Application to Drug Resistant Epilepsy
Original language description
Responsive neural stimulation (RNS) delivers electrical stimulation in a brain region in response to brain activity to treat neurological disorders. RNS directed at seizures and abnormal epileptiform activity proved to be successful in reducing seizures in drug resistant epilepsy, but efficacy optimization can be slow. There is ongoing interest in systems where stimulation paradigms and network targets are optimized adaptatively over time. Here we present a system where a cascade of detectors in implanted neural sensing and stimulation (INSS) device and a handheld device enabling machine learning seizure detection algorithms to adaptively control stimulation parameters and brain targets. We developed a system for multi-stage control over adaptive neurostimulation paradigms. The system utilizes an INSS with continuous real-time intracranial EEG (iEEG) recording and bi-directional communication with a handheld for off-device programmable control. The adaptive RNS settings on the INSS device engage multi
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
20601 - Medical engineering
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů