Characteristic Waveforms for Testing of Medical Aerosol Inhalers

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F20%3APU141506" target="_blank" >RIV/00216305:26220/20:PU141506 - isvavai.cz</a>
Result on the web
<a href="https://www.springerprofessional.de/en/characteristic-waveforms-for-testing-of-medical-aerosol-inhalers/18638550" target="_blank" >https://www.springerprofessional.de/en/characteristic-waveforms-for-testing-of-medical-aerosol-inhalers/18638550</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-030-64610-3_28" target="_blank" >10.1007/978-3-030-64610-3_28</a>

Result language
angličtina
Original language name
Characteristic Waveforms for Testing of Medical Aerosol Inhalers
Original language description
Respiratory diseases are characterised by high prevalence among the European population. Medical aerosol inhalers are the most commonly used means of drug delivery into the human respiratory system. This paper focuses on characteristic waveforms that can be utilised during aerosol deposition studies to simulate conditions of rapid human inhalation. Additionally, an inhalatory waveform based on clinically recorded spirometry data is introduced. Experimental measurements are performed and simulation results mutually compared using the electro-mechanical lung simulator xPULM™. The inhalatory waveforms are repeatably simulated with high fidelity in regards to the waveform shape with the lowest value of the Goodness of fit 0.89. Additionally, the measured values for all characteristic inhalatory parameters are simulated with low standard deviation σ < 1. The differences between the required and measured waveform shapes are small, ΔPIF < 3 L/min and do not influence the overall inhalatory volume. This opens a possibility of utilising the xPULM for medical aerosol inhalers testing.
Czech name
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Czech description
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Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
8th European Medical and Biological Engineering Conference
ISBN
978-3-030-64609-7
ISSN
1680-0737
e-ISSN
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Number of pages
6
Pages from-to
240-246
Publisher name
Springer Science and Business Media Deutschland GmbH
Place of publication
neuveden
Event location
Tampere
Event date
Jun 11, 2017
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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