Circadian Rhythms of Human Brain - Electrical Impedance
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F21%3APU142131" target="_blank" >RIV/00216305:26220/21:PU142131 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Circadian Rhythms of Human Brain - Electrical Impedance
Original language description
Rationale: Long-term data collection using implantable neural sense and stimulation (INSS) devices in patients with epilepsy enables investigation of ultradian, circadian and infradian rhythms in sleep, seizures, interictal epileptiform discharges (IED), and brain impedance. It has long been recognized that IED and seizures have circadian patterns. Recent studies also highlight the importance of circadian changes in brain extracellular space, and the functional role of slow-wave sleep and the associated increase in extracellular space volume that is hypothesized to provide improved metabolite and protein clearance. The direct evidence for increased extracellular space volume during sleep primarily comes from rodent studies, and a few human imaging studies with limited temporal sampling. Here we investigate a potential surrogate of extracellular volume, the brain electrical impedance in hippocampus (HPC) and anterior nucleus of thalamus (ANT) over multiple months in four ambulatory humans with drug res
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů