Carbon dots for in vivo fluorescence imaging of adipose tissue-derived mesenchymal stromal cells (vol 152, pg 434, 2019)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F21%3APU143958" target="_blank" >RIV/00216305:26220/21:PU143958 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Carbon dots for in vivo fluorescence imaging of adipose tissue-derived mesenchymal stromal cells (vol 152, pg 434, 2019)
Original language description
Tissue regeneration based on stem cell therapy is one of the most rapidly developing fields of modern medicine. Several properties of human mesenchymal stromal cells (MSCs), such as tropism toward a tumor or injury site, make them promising candidates for regenerative medicine, targeted therapy, or treating injured tissues. However, to fully understand the role of stem cells in therapeutic function, their visualization in vivo is essential. Here, we describe, for the first time, the use of biocompatible quaternized carbon dots (QCDs) as a novel stem-cell tracking probe for in vivo fluorescence imaging of transplanted human MSCs. By studying the in vitro cytotoxicity, intracellular distribution, and precise uptake mechanism, we showed that QCDs had a high biocompatibility and excellent fluorescence properties after 24 h incubation with MSCs. Further to demonstrate the in vivo feasibility of the system, QCD-labeled MSCs (100 mu g/mL of QCDs, 24 h incubation time) were transplanted subcutaneously into an
Czech name
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Czech description
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Project
<a href="/en/project/GA18-24089S" target="_blank" >GA18-24089S: Quantitative phase microscopy for 3D qualitative characterization of cancer cells</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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