Mitochondria morphology and membrane potential under stress conditions

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F22%3APU144418" target="_blank" >RIV/00216305:26220/22:PU144418 - isvavai.cz</a>
Result on the web
<a href="https://www.eeict.cz/eeict_download/archiv/sborniky/EEICT_2022_sbornik_1_v2.pdf" target="_blank" >https://www.eeict.cz/eeict_download/archiv/sborniky/EEICT_2022_sbornik_1_v2.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Mitochondria morphology and membrane potential under stress conditions
Original language description
Mitochondria, organelles found in the cytoplasm of almost all eukaryotic cells, generate large quantities of energy in the form of adenosine triphosphate (ATP). In addition to producing energy, mitochondria store calcium for cell signaling activities and play an important role in maintenance of ionic balance. Mitochondria, however, are highly sensitive to any kind of stress in which they mainly response by disturbance of respiration, reactive oxygen species (ROS) production and release of cytochrome c into the cytoplasm. Osmotic stress, in particular, generates ROS that degrade lipids, proteins, and DNA. High levels of salt concentration can cause an imbalance in cellular ion homeostasis that results in ion toxicity and osmotic stress. This study aims to investigate possible effects of KCl and NaCl on Bone marrow-derived (MSCs) mitochondria membrane potential (MMP) and morphology. The results indicated that KCl and NaCl of salt concentration can cause an imbalance in cellular ion homeostasis that resu
Czech name
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Czech description
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Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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