Systems biology approach for analysis of mobile genetic elements in chicken gut microbiome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F22%3APU146245" target="_blank" >RIV/00216305:26220/22:PU146245 - isvavai.cz</a>
Result on the web
<a href="https://doi.ieeecomputersociety.org/10.1109/BIBM55620.2022.9995414" target="_blank" >https://doi.ieeecomputersociety.org/10.1109/BIBM55620.2022.9995414</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1109/BIBM55620.2022.9995414" target="_blank" >10.1109/BIBM55620.2022.9995414</a>
Alternative languages
Result language
angličtina
Original language name
Systems biology approach for analysis of mobile genetic elements in chicken gut microbiome
Original language description
Antibiotic use in farming for decades has led to the selection pressure on chicken commensal bacteria which adapted to those changes by the acquisition of antibiotic resistance genes via horizontal gene transfer. Extensive gene transfer between gut bacteria is mediated by mobile genetic elements such as plasmids, integrative conjugative elements and temperate phages. Therefore, chicken gut commensal bacteria are considered reservoirs of antibiotic resistance genes. Recently, we initiated a systemic cultivation of chicken gut anaerobes followed by subsequent whole genome sequencing and analysis. In this study, we implemented a novel in silico approach using systems biology methods to detect horizontal gene traits and mobile genetic elements associated with it in the genomes of chicken gut commensals. In total, we identified 1,427 genes envisaged to drive horizontal gene transfer between individual chicken gut microbiota members across different families. Except for genes known to be vertically transferred, we also revealed hypothetical genes which may represent important, yet unknown section of mobilome
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
ISBN
978-1-4577-1799-4
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
2865-2870
Publisher name
IEEE Computer Society
Place of publication
neuveden
Event location
conference
Event date
Dec 6, 2022
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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