Activating NKG2C Receptor: Functional Characteristics and Current Strategies in Clinical Applications

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F23%3APU147897" target="_blank" >RIV/00216305:26220/23:PU147897 - isvavai.cz</a>

Result on the web

<a href="https://link.springer.com/article/10.1007/s00005-023-00674-z" target="_blank" >https://link.springer.com/article/10.1007/s00005-023-00674-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00005-023-00674-z" target="_blank" >10.1007/s00005-023-00674-z</a>

Result language

angličtina

Original language name

Activating NKG2C Receptor: Functional Characteristics and Current Strategies in Clinical Applications

Original language description

The interest in NK cells and their cytotoxic activity against tumour, infected or transformed cells continuously increases as they become a new efficient and off-the-shelf agents in immunotherapies. Their actions are balanced by a wide set of activating and inhibitory receptors, recognizing their complementary ligands on target cells. One of the most studied receptors is the activating CD94/NKG2C molecule, which is a member of the C-type lectin-like family. This review is intended to summarise latest research findings on the clinical relevance of NKG2C receptor and to examine its contribution to current and potential therapeutic strategies. It outlines functional characteristics and molecular features of CD94/NKG2C, its interactions with HLA-E molecule and presented antigens, pointing out a key role of this receptor in immunosurveillance, especially in the human cytomegalovirus infection. Additionally, the authors attempt to shed some light on receptor’s unique interaction with its ligand which is shared with another receptor (CD94/NKG2A) with rather opposite properties.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

ISSN

0004-069X

e-ISSN

1661-4917

Volume of the periodical

71

Issue of the periodical within the volume

1

Country of publishing house

PL - POLAND

Number of pages

18

Pages from-to

1-18

UT code for WoS article

000948365700001

EID of the result in the Scopus database

2-s2.0-85149932815