Evidence of functional Cd94 polymorphism in a free-living house mouse population
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F19%3A00503872" target="_blank" >RIV/68081766:_____/19:00503872 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s00251-018-01100-x" target="_blank" >http://dx.doi.org/10.1007/s00251-018-01100-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00251-018-01100-x" target="_blank" >10.1007/s00251-018-01100-x</a>
Alternative languages
Result language
angličtina
Original language name
Evidence of functional Cd94 polymorphism in a free-living house mouse population
Original language description
The CD94 receptor, expressed on natural killer (NK) and CD8+ T cells, is known as a relatively non-polymorphic receptor with orthologues in humans, other primates, cattle, and rodents. In the house mouse (Mus musculus), a single allele is highly conserved among laboratory strains, and reports of allelic variation in lab- or wild-living mice are lacking, except for deficiency in one lab strain (DBA/2J). The non-classical MHC-I molecule Qa-1b is the ligand for mouse CD94/NKG2A, presenting alternative non-americ fragment of leader peptides (Qa-1 determinant modifier (Qdm)) from classical MHC-I molecules. Here, we report a novel allele identified in free-living house mice captured in Norway, living among individuals carrying the canonical Cd94 allele. The novel Cd94(LocA) allele encodes 12 amino acid substitutions in the extracellular lectin-like domain. Flow cytometric analysis of primary NK cells and transfected cells indicates that the substitutions prevent binding of CD94 mAb and Qa-1b/Qdm tetramers. Our data further indicate correlation of Cd94 polymorphism with the two major subspecies of house mice in Europe. Together, these findings suggest that the Cd94(LocA)/NKG2A heterodimeric receptor is widely expressed among M. musculus subspecies musculus, with ligand-binding properties different from mice of subspecies domesticus, such as the C57BL/6 strain.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Immunogenetics
ISSN
0093-7711
e-ISSN
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Volume of the periodical
71
Issue of the periodical within the volume
4
Country of publishing house
DE - GERMANY
Number of pages
13
Pages from-to
321-333
UT code for WoS article
000462945600004
EID of the result in the Scopus database
2-s2.0-85058164690