Comparison of Pharmacokinetic Models for Quantification of Blood-Brain-Barrier Opening Induced by Focused Ultrasound

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F23%3APU148917" target="_blank" >RIV/00216305:26220/23:PU148917 - isvavai.cz</a>
Result on the web
<a href="https://www.eeict.cz/eeict_download/archiv/sborniky/EEICT_2023_sbornik_2_v2.pdf" target="_blank" >https://www.eeict.cz/eeict_download/archiv/sborniky/EEICT_2023_sbornik_2_v2.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.13164/eeict.2023.133" target="_blank" >10.13164/eeict.2023.133</a>

Result language
angličtina
Original language name
Comparison of Pharmacokinetic Models for Quantification of Blood-Brain-Barrier Opening Induced by Focused Ultrasound
Original language description
This paper focuses on quantification of blood-brain barrier (BBB) opening induced by focused ultrasound. Dynamic contrast-enhanced MRI (DCE-MRI) with two different pharmacokinetic models, 2CX and ETK, is used to evaluate BBB opening. The ETK model is commonly used in BBB-opening studies. We propose use of a more advanced model, 2CX, that provides more accurate estimation of the BBB permeability. The accuracy of the models is compared using simulated and real data. The results demonstrate similar performance of the 2CX and ETK models in the brain region with a highly permeable BBB, but the ETK has proven unable to correctly detect low level of permeabilization. Thus, the 2CX model is more suitable for the studies of BBB permeability dynamics.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings II of the 29th Conference STUDENT EEICT 2023 Selected papers
ISBN
978-80-214-6154-3
ISSN
2788-1334
e-ISSN
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Number of pages
4
Pages from-to
133-136
Publisher name
Brno University of Technology, Faculty of Electrical Engineering and Communication
Place of publication
Brno
Event location
Brno
Event date
Apr 25, 2023
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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