Focused ultrasound-induced blood-brain barrier opening: A comparative analysis of permeability quantification based on Ktrans and PS
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F25%3A00619015" target="_blank" >RIV/68081731:_____/25:00619015 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/25:00143801 RIV/00216305:26220/26:0197784
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/mrm.30446" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/mrm.30446</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mrm.30446" target="_blank" >10.1002/mrm.30446</a>
Alternative languages
Result language
angličtina
Original language name
Focused ultrasound-induced blood-brain barrier opening: A comparative analysis of permeability quantification based on Ktrans and PS
Original language description
Purpose: Focused ultrasound-induced blood-brain barrier (BBB) opening is a promising method for neurotherapeutic delivery. The standard for quantifying induced BBB permeability is the Ktrans parameter, which reflects both permeability and plasma flow. The influence of plasma flow can be eliminated by estimating the PS parameter. However, this parameter has been largely unexplored in this application. This study aims to compare permeability estimates based on Ktrans and PS in focused ultrasound-induced BBB opening experiments. Methods: We used the extended Tofts model (ETM) and the two-compartment exchange model (2CXM) to estimate Ktrans and PS parameters, respectively. Permeability estimates were compared using simulated concentration curves, simulated DCE-MRI data, and real datasets. We explored the influence of spatially-regularized model fitting on the results. Results: For opened BBB, Ktrans was minimally influenced by plasma flow under the tested conditions. However, fitting the ETM often introduced outliers in Ktrans estimates in regions with closed BBB. The 2CXM outperformed the ETM at high signal-to-noise ratios, but its higher complexity led to lower precision at low signal-to-noise ratios. Both these issues were successfully compensated by spatially-regularized model fitting. Conclusion: Both Ktrans and PS seem to be eligible options for the quantification of BBB opening, and the correct choice depends on the specifics of the acquired DCE-MRI data. Additionally, spatial regularization has demonstrated its importance in enhancing the accuracy and reproducibility of results for both models.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20601 - Medical engineering
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Magnetic Resonance in Medicine
ISSN
0740-3194
e-ISSN
1522-2594
Volume of the periodical
93
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
2610-2622
UT code for WoS article
001423256400001
EID of the result in the Scopus database
2-s2.0-85219742503