INFLUENCE OF PC3-DERIVED EXOSOMES ON FIBROBLAST PROLIFERATION AND MIGRATION

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F23%3APU149324" target="_blank" >RIV/00216305:26220/23:PU149324 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/24:43924927
Result on the web
<a href="https://doi.org/10.37904/nanocon.2023.4802" target="_blank" >https://doi.org/10.37904/nanocon.2023.4802</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.37904/nanocon.2023.4802" target="_blank" >10.37904/nanocon.2023.4802</a>

Result language
angličtina
Original language name
INFLUENCE OF PC3-DERIVED EXOSOMES ON FIBROBLAST PROLIFERATION AND MIGRATION
Original language description
Nano-sized exosomes are essential for intercellular communication, especially in cancer biology. Human produces exosomes that may modulate the tumor microenvironment and cellular behavior. This study examines how human prostate cancer cells (PC3) derived exosomes affect fibroblast proliferation and migration. Ultracentrifugation isolated exosomes from PC3 cell culture supernatants, which were characterized by confocal and transmission electron microscopy (TEM). Fibroblast cells were exposed to these PC3-derived exosomes. MTT [3–(4,5-dimethylthiazol-2yl)-2,5-diphenyl-2H-tetrazoliumbromide] was used to measure fibroblast proliferation, while another assay measured migration. PC3 exosomes appear to boost fibroblast proliferation and migration. Investigations into the molecular mechanisms behind these observations are ongoing. The study shows that PC3-derived exosomes can regulate fibroblast proliferation and migration. This study illuminates the effects of cancer cell-derived exosomes on cellular interactions and therapeutic potential.
Czech name
—
Czech description
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Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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