Mathematical modeling of the effect of stent construction during endoluminal IRE for recanalization of an occluded metal stent

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F26%3A0191287" target="_blank" >RIV/00216305:26220/26:0191287 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/25:00141725 RIV/65269705:_____/25:00082267

Result on the web

<a href="https://www.tandfonline.com/doi/metrics/10.1080/02656736.2025.2520362" target="_blank" >https://www.tandfonline.com/doi/metrics/10.1080/02656736.2025.2520362</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/02656736.2025.2520362" target="_blank" >10.1080/02656736.2025.2520362</a>

Result language

angličtina

Original language name

Mathematical modeling of the effect of stent construction during endoluminal IRE for recanalization of an occluded metal stent

Original language description

Background: Intraluminal irreversible electroporation (IRE) can be used for recanalizing occluded metalstents. However, optimal IRE parameters for consistent effects across different stent designs remainunclear. The aim of this study was to simulate the process of stent recanalization in silico by employingfinite element analysis. Methods: A virtual model of an occluded biliary stent with an experimental 3-electrode IRE catheter was developed. Electric field distribution, temperature changes, and potential ablation volumes weresimulated across various parameters: IRE voltage (300 − 1300 V), stent wire width (0.1 − 0.5 mm) and stentmesh size (0.7 − 5.58 mm). Simulations incorporated five representative stent types commonly used inclinical practice. 685 unique simulations were conducted, analyzing 1162 unique values. Results: Higher voltages generally led to larger ablation zones and increased temperatures. Thinnerstent wires and larger mesh sizes also increased the extent of ablation zone. While in-stent ablation waslargely independent of stent design, out-of-stent ablation was significantly impacted by mesh size andtissue thickness between the stent and irreversible electroporation electrodes. Voltages above 1000 Vproduced significant thermal effects, with substantial volumes of tissue heated above 50 °C. Specificstent designs exhibited variations in maximum temperature (72.1 − 83.1 °C) and ablation volume(8.7 − 14.7 mm3). Conclusion: Tailored IRE protocols for different stent designs are required due to differences in in- andout-stent ablation volumes. High voltages (>1000 V) induce both thermal and nonthermal ablation mechanisms.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30224 - Radiology, nuclear medicine and medical imaging

Project

<a href="/en/project/NU21-08-00561" target="_blank" >NU21-08-00561: The use of irreversible electroporation and high frequency irreversible electroporation for treatment of metal stent occlusion</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International journal of hyperthermia

ISSN

0265-6736

e-ISSN

1464-5157

Volume of the periodical

42

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

1-14

UT code for WoS article

001522021000001

EID of the result in the Scopus database

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