Nonlinear 3-D simulation of high-intensity focused ultrasound therapy in the kidney

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26230%2F16%3APU122417" target="_blank" >RIV/00216305:26230/16:PU122417 - isvavai.cz</a>

Result on the web

<a href="http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=7592008&isnumber=7590615" target="_blank" >http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=7592008&isnumber=7590615</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1109/EMBC.2016.7592008" target="_blank" >10.1109/EMBC.2016.7592008</a>

Result language

angličtina

Original language name

Nonlinear 3-D simulation of high-intensity focused ultrasound therapy in the kidney

Original language description

Kidney cancer is a severe disease which can be treated non-invasively using high-intensity focused ultrasound (HIFU) therapy. However, tissue in front of the transducer and the deep location of kidney can cause significant losses to the efficiency of the treatment. The effect of attenuation, refraction and reflection due to different tissue types on HIFU therapy of the kidney was studied using a nonlinear ultrasound simulation model. The geometry of the tissue was derived from a computed tomography (CT) dataset of a patient which had been segmented for water, bone, soft tissue, fat and kidney. The combined effect of inhomogeneous attenuation and sound-speed was found to result in an 11.0 dB drop in spatial peak-temporal average (SPTA) intensity in the kidney compared to pure water. The simulation without refraction effects showed a 6.3 dB decrease indicating that both attenuation and refraction contribute to the loss in focal intensity. The losses due to reflections at soft tissue interfaces were less than 0.1 dB. Focal point shifting due to refraction effects resulted in -1.3, 2.6 and 1.3 mm displacements in x-, y-and z-directions respectively. Furthermore, focal point splitting into several smaller subvolumes was observed. The total volume of the secondary focal points was approximately 46% of the largest primary focal point. This could potentially lead to undesired heating outside the target location and longer therapy times.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

—

OECD FORD branch

10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

38th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC)

ISBN

978-1-4577-0220-4

ISSN

—

e-ISSN

—

Number of pages

4

Pages from-to

5648-5651

Publisher name

Institute of Electrical and Electronics Engineers

Place of publication

Orlando

Event location

Lake Buena Vista (Orlando), Florida USA

Event date

Aug 16, 2016

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

000399823505243