Densitometry and ultrasound velocimetry of hyaluronan solutions in water and in sodium chloride solution

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F14%3APU109002" target="_blank" >RIV/00216305:26310/14:PU109002 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Densitometry and ultrasound velocimetry of hyaluronan solutions in water and in sodium chloride solution

Original language description

The densities of hyaluronan solutions in water and 0.15 M NaCl were measured in the temperature range from 25 to 50 C for the hyaluronan molecular weights from 10 to 1750 kDa. The density increased linearly with concentration and decreased with temperature. The data were fitted by the equation describing the density as a linear function of concentration and a quadratic function of temperature. The effect of molecular weight was negligible and thus single equation was sufficient to describe all data. The apparent and partial specific volumes were calculated from the density data including their extrapolated values to infinite dilutions. The measurement of ultrasound speed in the same solutions under the same conditions enabled to calculate the compressibility and its dependence on concentration and temperature. The compressibility decreased with both the concentration and the temperature but the effect of the concentration was only slight mild. The compressibility was used to estimate the hydration numbers which slightly decreased with increasing temperature and concentration. The addition of NaCl changed only the numerical values of density and ultrasound velocity while not changing the character of their dependence on temperature and concentration. Measured and calculated data indicate that hyaluronan does not disturb the specific water structure in the studied concentration range and support the idea of the existence of water clusters or nanodroplets hydrating the hyaluronan chains in solution.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10403 - Physical chemistry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Carbohydrate Polymers

ISSN

0144-8617

e-ISSN

1879-1344

Volume of the periodical

106

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

453-459

UT code for WoS article

000335620000059

EID of the result in the Scopus database

2-s2.0-84899052176