Self-Assembly Behavior of Negatively Charged Hyaluronan and Oppositely Charged Surfactants

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F14%3APU110562" target="_blank" >RIV/00216305:26310/14:PU110562 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Self-Assembly Behavior of Negatively Charged Hyaluronan and Oppositely Charged Surfactants
Original language description
Physico-chemical interactions between negatively charged hyaluronan and positively charged surfactant result in self-assembly nanoparticles formation. The aim of our study was to prepare and study hyaluronic acid nanoparticles based on electrostatic interactions with oppositely charged surfactant molecules. Interactions of hyaluronan and surfactants were investigated using dynamic light scattering and Laser Doppler Velocimetry methods. Titration experiments (size distribution and zeta potential measurement and isoelectric point) were utilized to explore the formation of aggregates. Aggregates formation is influenced by preparation of system. Different particles are formed if hyaluronan is added to surfactant solution or vice versa. Molecular weights ofhyaluronan have inconsiderable effect on interactions of components. If hyaluronan have a role of titrant, final particles are smaller than in the case of surfactant as titrant and can be more suitable for drug delivery applications. Pre
Czech name
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Czech description
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Project
<a href="/en/project/LD12068" target="_blank" >LD12068: Preparation of hyaluronan-micellar-aggregate colloids for nanomedical applications and characterization of their properties</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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