Hyaluronan-cetyltrimethylammonium bromide interactions in aqueous and physiological solution studied by fluorescence techniques

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F14%3APU113581" target="_blank" >RIV/00216305:26310/14:PU113581 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Hyaluronan-cetyltrimethylammonium bromide interactions in aqueous and physiological solution studied by fluorescence techniques
Original language description
The aim of this work was to study systems composed of negatively charged polyelectrolyte ? hyaluronan and positively charged surfactant ? cetyltrimethylammonium bromide (CTAB), which could be potential used for targeted drug delivery. Two concentration series was mixed ? in an aqueous solution and in 0.15 mol l-1 sodium chloride (simply physiological solution). In the series, the concentration of hyaluronan was constant and the concentration of CTAB (well below the critical micelle concentration in water solution) was increased. The interactions between these components were studied in terms of the formation of hydrophobic domains, which were important for solubilization of molecules of hydrophobic drugs. The intensity of fluorescence, steady-state anisotropy and lifetime of the samples were measured. Perylene was chosen as fluorescent probe due to its hydrophobicity. It was found that in aqueous solution, small hydrophobic domains linked to hyaluronan chains are formed. Then an increa
Czech name
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Czech description
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Project
<a href="/en/project/LD12068" target="_blank" >LD12068: Preparation of hyaluronan-micellar-aggregate colloids for nanomedical applications and characterization of their properties</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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