Optimization of derivatization of acidic drugs for analysis by GC-MS and its application for determination of drug residues in wastewater

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F15%3APU116561" target="_blank" >RIV/00216305:26310/15:PU116561 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Optimization of derivatization of acidic drugs for analysis by GC-MS and its application for determination of drug residues in wastewater

Original language description

This article is focused on optimization of derivatization of acidic drugs from the group of non-steroidal anti-inflammatory drugs (NSAID): salicylic acid, ibuprofen, naproxen, ketoprofen and diclofenac. Derivatization is a necessary step for analysis of pharmaceuticals by GC. MSTFA (N-methylN-(trimethylsilyl)trifluoroacetamide) and BSTFA (N,Obis(trimethylsilyl)trifluoroacetamide) were used as a derivatization reagents and tested under different conditions: volume, temperature and time of derivatization. Results of optimization were compared and optimized conditions were successfully applied for analysis of real samples of wastewater. Wastewater samples were collected from influent and effluent of wastewater treatment plant (WWTP). The whole analytical procedure involved solid phase extraction (SPE), optimized derivatization and analysis by GC-TOF MS. Limits of detection (LOD) ranged between 8.9 - 71.6 ng.L-1 and limits of quantification (LOQ) ranged between 29.5 – 238.7 ng.L-1 depending on the specific compound. Concentration of selected drugs in real samples of wastewater varied from 0.1 to 30 g.L-1 in influent and from 0.05 to 2 g.L-1 in effluent, depending on the compound.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10500 - Earth and related environmental sciences

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Fresenius Environmental Bulletin

ISSN

1018-4619

e-ISSN

1610-2304

Volume of the periodical

24

Issue of the periodical within the volume

11a

Country of publishing house

DE - GERMANY

Number of pages

9

Pages from-to

3813-3821

UT code for WoS article

000367698500014

EID of the result in the Scopus database

2-s2.0-84958179344