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The Effect of PLGA-PEG-PLGA Modification on the Sol-gel Transition and Degradation Properties

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F16%3APU116586" target="_blank" >RIV/00216305:26310/16:PU116586 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.expresspolymlett.com/" target="_blank" >http://www.expresspolymlett.com/</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3144/expresspolymlett.2016.34" target="_blank" >10.3144/expresspolymlett.2016.34</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The Effect of PLGA-PEG-PLGA Modification on the Sol-gel Transition and Degradation Properties

  • Original language description

    This paper deals with the influence of an incubation medium pH on the hydrolytic degradation of a novel thermosensitive biodegradable triblock copolymer based on hydrophilic poly(ethylene glycol) and hydrophobic copolymer poly(lactic acid-co-glycolic acid) (PLGA-PEG-PLGA), consequently modified at alpha,omega-ends with itaconic acid (ITA) resulting in alpha,omega-itaconyl(PLGA-PEG-PLGA). Itaconic acid, gained from renewable resources, delivers a reactive double bond and carboxylic functional group to the end of PLGA-PEG-PLGA copolymer: this is important for a reaction with biologically active substances. The suitability of the sample degradation was assessed depending on whether the copolymer formed a gel at 37 °C. Two reversible physical sol-gel-sol transitions from a sol (liquid phase) to a gel (solid phase) and back to a sol (suspension) were verified using the tube inverting method. The hydrolytical degradation was evaluated at a physiological temperature (37 °C) in the presence of phosphate solutions, at a pH either 4.2 or 7.4 by monitoring the decrease of the number average molecular weight of copolymers by GPC. Moreover, the degradation kinetics was confirmed by the HPLC/DAD method, where the increasing amount of final degradation products (lactic and glycolic acids) was detected. The study demonstrated that the carboxylic groups modified copolymer is more susceptible to hydrolytical degradation than the unmodified copolymer within first days of degradation at 7.4.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10406 - Analytical chemistry

Result continuities

  • Project

    <a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    EXPRESS POLYM LETT

  • ISSN

    1788-618X

  • e-ISSN

  • Volume of the periodical

    10

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    HU - HUNGARY

  • Number of pages

    12

  • Pages from-to

    361-372

  • UT code for WoS article

    000371669000002

  • EID of the result in the Scopus database

    2-s2.0-84959370881