The Effect of PLGA-PEG-PLGA Modification on the Sol-gel Transition and Degradation Properties
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F16%3APU116586" target="_blank" >RIV/00216305:26310/16:PU116586 - isvavai.cz</a>
Result on the web
<a href="http://www.expresspolymlett.com/" target="_blank" >http://www.expresspolymlett.com/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3144/expresspolymlett.2016.34" target="_blank" >10.3144/expresspolymlett.2016.34</a>
Alternative languages
Result language
angličtina
Original language name
The Effect of PLGA-PEG-PLGA Modification on the Sol-gel Transition and Degradation Properties
Original language description
This paper deals with the influence of an incubation medium pH on the hydrolytic degradation of a novel thermosensitive biodegradable triblock copolymer based on hydrophilic poly(ethylene glycol) and hydrophobic copolymer poly(lactic acid-co-glycolic acid) (PLGA-PEG-PLGA), consequently modified at alpha,omega-ends with itaconic acid (ITA) resulting in alpha,omega-itaconyl(PLGA-PEG-PLGA). Itaconic acid, gained from renewable resources, delivers a reactive double bond and carboxylic functional group to the end of PLGA-PEG-PLGA copolymer: this is important for a reaction with biologically active substances. The suitability of the sample degradation was assessed depending on whether the copolymer formed a gel at 37 °C. Two reversible physical sol-gel-sol transitions from a sol (liquid phase) to a gel (solid phase) and back to a sol (suspension) were verified using the tube inverting method. The hydrolytical degradation was evaluated at a physiological temperature (37 °C) in the presence of phosphate solutions, at a pH either 4.2 or 7.4 by monitoring the decrease of the number average molecular weight of copolymers by GPC. Moreover, the degradation kinetics was confirmed by the HPLC/DAD method, where the increasing amount of final degradation products (lactic and glycolic acids) was detected. The study demonstrated that the carboxylic groups modified copolymer is more susceptible to hydrolytical degradation than the unmodified copolymer within first days of degradation at 7.4.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
EXPRESS POLYM LETT
ISSN
1788-618X
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
5
Country of publishing house
HU - HUNGARY
Number of pages
12
Pages from-to
361-372
UT code for WoS article
000371669000002
EID of the result in the Scopus database
2-s2.0-84959370881