Occurence of Macrolide Antibiotics in Waste Water

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F17%3APU124240" target="_blank" >RIV/00216305:26310/17:PU124240 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Occurence of Macrolide Antibiotics in Waste Water

Original language description

Antibiotics are pharmaceuticals used to treat diseases caused by bacteria. They are widely used in human and veterinary medicine. Macrolides are after penicillins the second most prescribed group of antibiotics in the Czech Republic. After administration, the drugs are excreted from the body in the form of metabolites or unchanged via urine or feces. These compounds are then discharged into the waste water and in most cases enter the wastewater treatment plants (WWTPs). Antibiotic can negatively affect biological processes of treatment, where microorganisms are essential for proper functioning WWTP. In many cases the efficiency of antibiotics removal is not sufficient, thus WWTPs are considered as major point sources of environmental contamination by these compounds. The presence of antibiotics in the environment can lead to the development of bacterial resistance to antibiotics which is one of the biggest threats to mankind nowadays. In this work, we examined the presence of macrolide antibiotics (azithromycin, clarithromycin, erythromycin and roxithromycin) in waste water (in both, inflow and outflow from treatment plant) from three different WWTPs – WWTP Brno-Modřice, WWTP Mikulov and WWTP of The University of Veterinary and Pharmaceutical Sciences Brno. As pre-concentration step was used solid phase extraction (SPE) and HPLC coupled to MS detection was used as a final analytical technique. The total occurrence of macrolides in 26 collected samples was 100 % for azithromycin, clarithromycin and erythromycin and 96 % for roxithromycin. In general, the highest concentrations were observed in WWTP of Brno-Modřice and the lowest concentrations were determined in WWTP of The University of Veterinary and Pharmaceutical Sciences Brno. The comparison of concentrations of individual substances shows, that the concentrations of azithromycin and clarithromycin were one or two orders of magnitude higher than the concentrations of erythromycin and roxithromycin (concentration

Czech name

—

Czech description

—

Type

A - Audiovisual production

CEP classification

—

OECD FORD branch

10511 - Environmental sciences (social aspects to be 5.7)

Project

<a href="/en/project/LO1408" target="_blank" >LO1408: AdMaS UP – Advanced Building Materials, Structures and Technologies</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

ISBN

—

Place of publication

Brno

Publisher/client name

Neuveden

Version

Neuveden

Carrier ID

—