The effect of pH and multivalent ions on the mechanical properties of gels with micellar nanodomains

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F18%3APU131470" target="_blank" >RIV/00216305:26310/18:PU131470 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The effect of pH and multivalent ions on the mechanical properties of gels with micellar nanodomains
Original language description
The aim of this study was to examine the properties and behaviour of phase-separated hydrogels. These can be prepared by interaction of specific biopolymer (sodium hyaluronate – Hya) with oppositely charged surfactant (carbethopendecinium bromide – Septonex). Using the method of rheology, the effect of pH and addition of multivalent ions to the mixture of Hya-Septonex, was studied. Samples underwent both oscillatory and flow measurements. Generally, pH suppressed the elasticity of Hya-Septonex hydrogels by decreasing both the elastic and viscous moduli in comparison to standard pH-uncontrolled samples. Molecular weight of polymer has also direct influence in presence of pH influence. Higher molecular weight of hyaluronan caused the elastic modulus to be higher than viscous even in case of lower pH. However, using the pH around or below the pKa of Hya (pH=3.5) caused that the most of the COO- groups of Hya were not dissociated, thus the gels were not formed. On the other hand, higher pH (pH=9) resulted
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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