CYTOTOXIC AND GENOTOXIC EFFECTS OF LIPOSOME PARTICLES WITH ENCAPSULATED NATURAL EXTRACTS

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F18%3APU140010" target="_blank" >RIV/00216305:26310/18:PU140010 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
CYTOTOXIC AND GENOTOXIC EFFECTS OF LIPOSOME PARTICLES WITH ENCAPSULATED NATURAL EXTRACTS
Original language description
Easy scale up of production led to an increase in cosmetic industry interest in lipid nanostructures. There are currently some liposome formulations on the market and the amount of these products will indoubtedly continue to grow. For this, detailed studies about their potential genotoxicity and cytotoxicity are neccesary. Presented work deals with preparation and characterization of liposome particles with aqueous and oil extracts of plant origin. The aim of this work was to observe cytotoxic and genotoxic effects of prepared liposomes. Total phenolics, flavonoids and antioxidant activity of plant extracts were determined using spectrophotometry as well as encapsulation efficiency. Stability of liposome particles was evaluated using zeta potential and size of liposomes was determined by dynamic light scattering. Potential genotoxic effects of liposomes were analysed using SOS Chromotest. Cytotoxicity of liposome particles was observed in human epidermal keratinocytes HEK (102-05a). Micro- and nanoparticles with encapsulated antioxidant and antimicrobial active compounds can enhance the effectiveness of cosmetics and pharmaceuticals. In this work, the potential use of liposome particles with natural plant extracts in appropriate concentration was proposed.
Czech name
—
Czech description
—

Project
<a href="/en/project/LO1211" target="_blank" >LO1211: Materials Research Centre at FCH BUT- Sustainability and Development</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings Paper, 10TH ANNIVERSARY INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION (NANOCON 2018 (R))
ISBN
978-80-87294-89-5
ISSN
—
e-ISSN
—
Number of pages
6
Pages from-to
739-744
Publisher name
Tanger, a.s.
Place of publication
TANGER LTD, KELTICKOVA 62, SLEZSKA, OSTRAVA 710
Event location
Brno
Event date
Oct 17, 2018
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
—

Similar results(10)