Fabrication of novel PHB-liposome nanoparticles and study of their toxicity in vitro

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F19%3APU131383" target="_blank" >RIV/00216305:26310/19:PU131383 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s11051-019-4484-7" target="_blank" >http://dx.doi.org/10.1007/s11051-019-4484-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11051-019-4484-7" target="_blank" >10.1007/s11051-019-4484-7</a>

Result language
angličtina
Original language name
Fabrication of novel PHB-liposome nanoparticles and study of their toxicity in vitro
Original language description
n this work, novel combined PHB-liposome nanoparticles were synthesized and characterized, and their biocompatability with mammalian cells was assessed in vitro. Incorporation of PHB into liposome particles led to preservation of small size (123.8 ± 0.9 nm; evaluated by DLS) and colloidal stability of particles for 2 months in water environment. Cytotoxicity studies using MTT test with two different skin keratinocytes cell lines (HEK and HaCaT) showed significant dose-dependent differences in cell viability after exposure to liposome and PHB liposome particles in vitro.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21001 - Nano-materials (production and properties)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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