Oect multielectrode array for real-time cell culture monitoring
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F19%3APU136047" target="_blank" >RIV/00216305:26310/19:PU136047 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/19:00523258
Result on the web
<a href="https://www.scopus.com/record/display.uri?eid=2-s2.0-85062984835&origin=resultslist&sort=plf-f&src=s&sid=44723808f725a148aba6e39e5457150f&sot=autdocs&sdt=autdocs&sl=17&s=AU-ID%288378482500%29&relpos=8&citeCnt=0&searchTerm=" target="_blank" >https://www.scopus.com/record/display.uri?eid=2-s2.0-85062984835&origin=resultslist&sort=plf-f&src=s&sid=44723808f725a148aba6e39e5457150f&sot=autdocs&sdt=autdocs&sl=17&s=AU-ID%288378482500%29&relpos=8&citeCnt=0&searchTerm=</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Oect multielectrode array for real-time cell culture monitoring
Original language description
The significant cost of newly developed pharmacological products is due to the toxicity examination performed on animals in pre-clinical trials. Our ultimate goal is to develop a biosensor array to determine acute cardiotoxicity. It capitalizes on the fact that heart muscle cells (cardiomyocytes) show beating in vitro. Based on the beating characteristics their pathophysiological status can be deducted. In addition to microscopic imaging, the method of monitoring the action and field potential of synchronously beating cardiomyocyte syncytia on multielectrode arrays (MEA) appears to be a suitable method for the investigation of the condition of cardiac cells. For this purpose, MEA on the basis of organic electrochemical transistors (OECTs) has been developed. The organic polymer PEDOT:PSS was utilized to meet the strict surface biocompatibility demand for a surface in contact with media and living cardiac cells. The MEA consisted of a microplate of a 12x8 chimney-well array with transistors on the bottom for cell cultivation. For the fabrication (a screen printing method) primarily a contact field and an organic polymer was used. The device was tested in a simulation mode for the response of the drain current to the voltage pulses applied to the gate electrode up to 100 mu V. The response to such gate voltage renders the device sensitive enough to detect the electrical signal of beating cardiomyocytes. Further development is directed towards higher time resolution by means of miniaturization of the transistors' channel.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
21002 - Nano-processes (applications on nano-scale); (biomaterials to be 2.9)
Result continuities
Project
<a href="/en/project/GA17-24707S" target="_blank" >GA17-24707S: Novel natrure-inspired organic semiconductors for bioelectronics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
NANOCON 2018 - Conference Proceedings
ISBN
978-80-872-9489-5
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
336-341
Publisher name
TANGER Ltd.
Place of publication
Brno
Event location
Brno
Event date
Oct 17, 2018
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000513131900058