Micellar nanocarriers based on hydrophobical hyaluronan

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F19%3APU137523" target="_blank" >RIV/00216305:26310/19:PU137523 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Micellar nanocarriers based on hydrophobical hyaluronan
Original language description
This work studies the properties of modified biopolymers for potential use in targeted drug delivery. Various samples of hydrophobically modified hyaluronan with different degree of substitution were selected. The critical aggregation concentration (CAC) of these samples was measured using fluorescence spectroscopy, wherein it was found that micelle formation occurs over a wide concentration region. Environment of 0.15 M NaCl causes the decrease of CAC only slightly or not at all. The results were confirmed by measuring the dynamic light scattering, which also showed an increase in the size of aggregates with an increasing concentration. One of the samples exhibited a double size distribution. Zeta potential measurements provide information about stability of the samples. The results of this study confirm that the studied samples seem to be a suitable candidates for the post of drug carrier for targeted delivery.
Czech name
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Czech description
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Project
<a href="/en/project/LO1211" target="_blank" >LO1211: Materials Research Centre at FCH BUT- Sustainability and Development</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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