Assessing Lettuce Exposure to a Multi-Pharmaceutical Mixture in Soil: Insights from LC-ESI-TQ Analysis and the Impact of Biochar on Pharmaceutical Bioavailability

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F24%3APU151989" target="_blank" >RIV/00216305:26310/24:PU151989 - isvavai.cz</a>

Result on the web

<a href="https://pubs.acs.org/doi/10.1021/acsomega.4c05831" target="_blank" >https://pubs.acs.org/doi/10.1021/acsomega.4c05831</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsomega.4c05831" target="_blank" >10.1021/acsomega.4c05831</a>

Result language

angličtina

Original language name

Assessing Lettuce Exposure to a Multi-Pharmaceutical Mixture in Soil: Insights from LC-ESI-TQ Analysis and the Impact of Biochar on Pharmaceutical Bioavailability

Original language description

Agricultural practices introduce pharmaceutical (PhAC) residues into the terrestrial environment, potentially endangering agricultural crops and human health. This study aimed to evaluate various aspects related to the presence of pharmaceuticals in the lettuce-soil system, including bioconcentration factors (BCFs), translocation factors (TFs), ecotoxicological effects, the influence of biochar on the PhAC bioavailability, persistence in soil, and associated environmental and health risks. Lettuce (Lactuca sativa L.) was exposed to a mixture of 25 PhACs in two scenarios: initially contaminated soil (ranging from 0 to 10,000 ng center dot g(-1)) and soil irrigated with contaminated water (ranging from 0 to 1000 mu g center dot L-1) over a 28-day period. The findings revealed a diverse range of BCFs (0.068-3.7) and TFs (0.032-0.58), indicating the uptake and translocation potential of pharmaceuticals by lettuce. Significant ecotoxicological effects on L. sativa, including weight change and increased mortality, were observed (p < 0.05). Interestingly, biochar did not significantly affect PhAC uptake by L. sativa (p > 0.05), while it significantly influenced the soil degradation kinetics of 12 PhACs (p < 0.05). Additionally, the estimated daily intake of PhACs through the consumption of L. sativa suggested negligible health risks, although concerns arose regarding the potential health risks if other vegetable sources were similarly contaminated with trace residues. Furthermore, this study evaluated the environmental risk associated with the emergence of antimicrobial resistance (AMR) in soil, as medium to high. In conclusion, these findings highlight the multifaceted challenges posed by pharmaceutical contamination in agricultural environments and emphasize the importance of proactive measures to mitigate the associated risks to both environmental and human health.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10406 - Analytical chemistry

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ACS OMEGA

ISSN

2470-1343

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

37

Country of publishing house

US - UNITED STATES

Number of pages

17

Pages from-to

39065-39081

UT code for WoS article

001306478900001

EID of the result in the Scopus database

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