Microcalorimetry as an Effective Tool for the Determination of Thermodynamic Characteristics of Fulvic–Drug Interactions

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F24%3APU154966" target="_blank" >RIV/00216305:26310/24:PU154966 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2227-9717/13/1/49" target="_blank" >https://www.mdpi.com/2227-9717/13/1/49</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/pr13010049" target="_blank" >10.3390/pr13010049</a>

Result language

angličtina

Original language name

Microcalorimetry as an Effective Tool for the Determination of Thermodynamic Characteristics of Fulvic–Drug Interactions

Original language description

The presence of pharmaceuticals in the environment can result in potentially dangerous situations. In soils and sediments, pharmaceuticals can be partially immobilized by interactions with humic substances. Interactions, thus, can strongly affect their mobility and bioavailability. An investigation of the thermodynamic aspects of the interactions is largely missing. Thermodynamic parameters are usually calculated on the basis of sorption experiments. Our study is focused on the direct measurements of the heat effect of interactions between fulvic acids and chosen drugs. Well-characterized fulvic sample standards provided by the International Humic Substances Society were used. Ibuprofen, diclofenac, and sulphapyridine were chosen as drugs. Isothermal titration calorimetry provided a complete set of thermodynamic characteristics of underlying processes—interaction enthalpy, entropy, and Gibbs energy. All studied interactions were found to be exothermic with heat liberation between −496 and −9938 J/mol. The lowest enthalpies were obtained for sulphapyridine and the highest ones for ibuprofen (on average). Changes in Gibbs energy were very similar for all studied interactions (20–28 kJ/mol). The highest change in entropy was determined for ibuprofen (73 J/mol·K); values obtained for diclofenac and sulphapyridine were comparable (57 and 56 J/mol·K, respectively).

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10403 - Physical chemistry

Project

<a href="/en/project/LO1211" target="_blank" >LO1211: Materials Research Centre at FCH BUT- Sustainability and Development</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Processes

ISSN

2227-9717

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

1

Country of publishing house

CH - SWITZERLAND

Number of pages

11

Pages from-to

„“-„“

UT code for WoS article

001403837100001

EID of the result in the Scopus database

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