STUDY COVALENT INTERACTIONS FRAGMENT. DNA WITH CISPLATIN
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F12%3APU126954" target="_blank" >RIV/00216305:26620/12:PU126954 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
STUDY COVALENT INTERACTIONS FRAGMENT. DNA WITH CISPLATIN
Original language description
This work was focused on monitoring of covalent cisplatin bonding with lambda DNA fragment. The PCR fragment with a length of 498 bp and 100 uM cisplatin infusion solution was used. Interactions of DNA fragment were observed electrophoreticallyand spectrophotometrically. Experiments show, that during denaturation, cisplatin significantly reduces the melting temperature of DNA fragment. The average melting temperature was determined to 71 degrees C. After addition of cisplatin (100 uM), temperaturedecreased by 15 degrees C on average.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
40201 - Animal and dairy science; (Animal biotechnology to be 4.4)
Result continuities
Project
<a href="/en/project/GAP102%2F11%2F1068" target="_blank" >GAP102/11/1068: Nano-Electro-Bio-Tools for Biochemical and Molecularly-Biological Studies of Eukaryotic Cells (NanoBioTECell)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
MENDELNET 2012
ISBN
978-80-7375-836-3
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
1244-1249
Publisher name
Neuveden
Place of publication
Neuveden
Event location
Mendel Univ, Fac Agron, Brno
Event date
Nov 21, 2012
Type of event by nationality
CST - Celostátní akce
UT code for WoS article
000366461200145