Cell type specificity of neurovascular coupling in cerebral cortex

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F16%3APU119612" target="_blank" >RIV/00216305:26620/16:PU119612 - isvavai.cz</a>

Result on the web

<a href="https://elifesciences.org/content/5/e14315" target="_blank" >https://elifesciences.org/content/5/e14315</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7554/elife.14315" target="_blank" >10.7554/elife.14315</a>

Result language

angličtina

Original language name

Cell type specificity of neurovascular coupling in cerebral cortex

Original language description

Identification of the cellular players and molecular messengers that communicate neuronal activity to the vasculature driving cerebral hemodynamics is important for (1) the basic understanding of cerebrovascular regulation and (2) interpretation of functional Magnetic Resonance Imaging (fMRI) signals. Using a combination of optogenetic stimulation and 2-photon imaging in mice, we demonstrate that selective activation of cortical excitation and inhibition elicits distinct vascular responses and identify the vasoconstrictive mechanism as Neuropeptide Y (NPY) acting on Y1 receptors. The latter implies that task-related negative Blood Oxygenation Level Dependent (BOLD) fMRI signals in the cerebral cortex under normal physiological conditions may be mainly driven by the NPY-positive inhibitory neurons. Further, the NPY-Y1 pathway may offer a potential therapeutic target in cerebrovascular disease.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10306 - Optics (including laser optics and quantum optics)

Project

<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

eLife

ISSN

2050-084X

e-ISSN

—

Volume of the periodical

5

Issue of the periodical within the volume

-

Country of publishing house

GB - UNITED KINGDOM

Number of pages

23

Pages from-to

1-23

UT code for WoS article

000380279800001

EID of the result in the Scopus database

2-s2.0-84979516858