Generation of humanized bone-marrow-like niche in immunodeficient mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F17%3APU126684" target="_blank" >RIV/00216305:26620/17:PU126684 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Generation of humanized bone-marrow-like niche in immunodeficient mice

Original language description

Imunodeficient mice represent a standard in vivo model for study of different types of human leukemias. Not all leukemic cells, however, do engraft/proliferate after xenotransplantation to mice, which is supposedly caused by inter-species differences. This problem can be resolved by introducing a humanized microenvironment into the animal recipients, via sub-cutaneous implantation of a suitable biomaterial and human mesenchymal stromal cells (MSC).

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

30402 - Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

Project

<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů