Ruthenium-based core-shell nanoparticles with exceptional in vitro biocompatibility
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F17%3APU128344" target="_blank" >RIV/00216305:26620/17:PU128344 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/17:43912620
Result on the web
<a href="https://mendelnet.cz/artkey/mnt-201701-0092_Ruthenium-based-core-shell-nanoparticles-with-exceptional-in-vitro-biocompatibility.php?back=/magno/mnt/2017/mn1.php?secid=4" target="_blank" >https://mendelnet.cz/artkey/mnt-201701-0092_Ruthenium-based-core-shell-nanoparticles-with-exceptional-in-vitro-biocompatibility.php?back=/magno/mnt/2017/mn1.php?secid=4</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Ruthenium-based core-shell nanoparticles with exceptional in vitro biocompatibility
Original language description
The current study demonstrates design preparation and characterization of biocompatible hybrid ruthenium core-shell nanoparticles (RuNPs) coated with polyvinylpyrrolidone (PVP) and polyoxyethylene stearate (POES). The resulting RuNPs were loaded with doxorubicin, as model anticancer drug. Resulting complex has an exceptional stability in physiological conditions. The cytotoxic effects of the complex were tested using cell lines representing breast and ovarian cancers and neuroblastoma. Although bare RuNPs had only negligible cytotoxicity, RuPDox caused an enhancement of doxorubicin cytotoxicity when compared to free doxorubicin. RuPDox promoted significantly increased stability of doxorubicin in human plasma and pronounced hemocompatibility assayed on human red blood cells. Results demonstrate that biocompatible RuNPs could have a great potential as versatile nanoplatform to enhance efficiency of anticancer therapy.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
MendelNet 2017
ISBN
978-80-7509-529-9
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
837-842
Publisher name
Mendel University in Brno
Place of publication
Neuveden
Event location
Brno
Event date
Nov 8, 2017
Type of event by nationality
CST - Celostátní akce
UT code for WoS article
000440194500150