Effect of surfactants and polymers on stability of superparamagnetic nanoparticles and on immobilization and release of antitumor agents

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F18%3A43914709" target="_blank" >RIV/62156489:43210/18:43914709 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/19:PU131630
Result on the web
<a href="https://mnet.mendelu.cz/mendelnet2018/mnet_2018_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2018/mnet_2018_full.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Effect of surfactants and polymers on stability of superparamagnetic nanoparticles and on immobilization and release of antitumor agents
Original language description
The current study demonstrates design, preparation and characterization of biocompatible superparamagnetic iron oxide nanoparticles (SPIONs) coated with three different polymers polyvinylpyrrolidone (PVP) polyoxyethylene stearate (POES) and chitosan (Chit). Such modified nanoparticles were loaded with doxorubicin, as model anticancer drug. Resulting complex has an exceptional stability in physiological conditions. The highest release of complexed Dox was in endosomal environment in case SPIONs with POES. The cytotoxic effects of the complex were tested using breast cancer/healthy epithelial cell lines. Use of SPIONs increased the cytotoxicity of doxorubicin when compared to free doxorubicin and decreased the cytotoxicity in healthy cells. The results demonstrate that modification of SPIONs could have a potential in nanomedicine as versatile nanoplatform to enhance efficiency of anticancer therapy.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
MendelNet 2018: Proceedings of International PhD Students Conference
ISBN
978-80-7509-597-8
ISSN
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e-ISSN
neuvedeno
Number of pages
6
Pages from-to
489-494
Publisher name
Mendelova univerzita v Brně
Place of publication
Brno
Event location
Brno
Event date
Nov 7, 2018
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
000462205300093

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