Development and characterization of metal oxide nanoparticles for the delivery of anticancer drug

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43410%2F16%3A43909212" target="_blank" >RIV/62156489:43410/16:43909212 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3109/21691401.2014.978980" target="_blank" >http://dx.doi.org/10.3109/21691401.2014.978980</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/21691401.2014.978980" target="_blank" >10.3109/21691401.2014.978980</a>

Result language

angličtina

Original language name

Development and characterization of metal oxide nanoparticles for the delivery of anticancer drug

Original language description

The aim of the study was to prepare chemotherapeutic agent-loaded zinc oxide nanoparticles for the intracellular delivery of drug, for better therapeutic activity. Zinc oxide nanoparticles have inherent anticancer properties, hence it was envisaged that by loading the anticancer drug into zinc oxide nanoparticles, enhanced anticancer activity might be observed. Zinc oxide nanoparticles were prepared using zinc nitrate and sodium hydroxide. Starch was used as the stabilizing agent. The nanoparticles prepared were characterized for size, shape, entrapment efficiency, and drug release. Further, cell line studies were performed to evaluate cellular uptake and cytotoxicity profile using MCF-7 cells. A hemolysis study was performed to check the acute toxicity of the nanoparticles. The nanoparticles were found to be 476.4 +/- 2.51 nm in size, with low PDI (0.312 +/- 0.02) and high entrapment efficiency (> 85%). The nanoparticles were stable, and did not form aggregates on storage in the dispersed form. A cytotoxicity study demonstrated that drug-loaded zinc oxide nanoparticles exhibited higher anticancer activity as compared to either blank zinc oxide nanoparticles and doxorubicin (DOX) alone, or their mixture. A hemolytic test revealed that the prepared zinc oxide nanoparticles caused negligible hemolysis. Thus, it can be concluded that zinc oxide nanoparticles loaded with DOX resulted in better uptake of the chemotherapeutic agent, and at the same time, showed low toxicity towards normal cells.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Artificial Cells, Nanomedicine and Biotechnology

ISSN

2169-1401

e-ISSN

—

Volume of the periodical

44

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

672-679

UT code for WoS article

000370635000031

EID of the result in the Scopus database

2-s2.0-84964337083