Accelerated hardening of nanotextured 3D-plotted self-setting calcium phosphate inks
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F18%3APU128735" target="_blank" >RIV/00216305:26620/18:PU128735 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.actbio.2018.05.042" target="_blank" >https://doi.org/10.1016/j.actbio.2018.05.042</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.actbio.2018.05.042" target="_blank" >10.1016/j.actbio.2018.05.042</a>
Alternative languages
Result language
angličtina
Original language name
Accelerated hardening of nanotextured 3D-plotted self-setting calcium phosphate inks
Original language description
Direct ink writing (DIW) techniques open up new possibilities for the fabrication of patient-specific bone grafts. Self-setting calcium phosphate inks, which harden at low temperature, allow obtaining nanostructured scaffolds with biomimetic properties and enhanced bioactivity. However, the slow hardening kinetics hampers the translation to the clinics. Different hydrothermal treatments for the consolidation of DIW scaffolds fabricated with an a-tricalcium phosphate /pluronic F127 ink were explored, comparing them with a biomimetic treatment. Three different scaffold architectures were analysed. The hardening process, associated to the conversion of a-tricalcium phosphate to hydroxyapatite was drastically accelerated by the hydrothermal treatments, reducing the time for complete reaction from 7 days to 30 minutes, while preserving the scaffold architectural integrity and retaining the nanostructured features. b-tricalcium phosphate was formed as a secondary phase, and a change of morphology from plate-like to needle-like crystals in the hydroxyapatite phase was observed. The binder was largely released during the treatment. The hydrothermal treatment resulted in a 30% reduction of the compressive strength, associated to the residual presence of b-tricalcium phosphate. Biomimetic and hydrothermally treated scaffolds supported the adhesion and proliferation of rat mesenchymal stem cells, indicating a good suitability for bone tissue engineering applications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30404 - Biomaterials (as related to medical implants, devices, sensors)
Result continuities
Project
<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Biomaterialia
ISSN
1742-7061
e-ISSN
1878-7568
Volume of the periodical
1
Issue of the periodical within the volume
75
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
451-462
UT code for WoS article
000440125600037
EID of the result in the Scopus database
2-s2.0-85048559418