Scaffold microstructure evolution via freeze-casting and hydrothermal phase transformation of calcium phosphate

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F24%3APU155966" target="_blank" >RIV/00216305:26620/24:PU155966 - isvavai.cz</a>

Result on the web

<a href="https://ceramics.onlinelibrary.wiley.com/doi/10.1111/jace.20053" target="_blank" >https://ceramics.onlinelibrary.wiley.com/doi/10.1111/jace.20053</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jace.20053" target="_blank" >10.1111/jace.20053</a>

Result language

angličtina

Original language name

Scaffold microstructure evolution via freeze-casting and hydrothermal phase transformation of calcium phosphate

Original language description

Extensive research efforts have been focused on customizing the microstructure, macrostructure, and phase composition of calcium phosphate for enhanced biocompatibility and bioactivity in scaffolds for bone substitutes. Despite significant progress, achieving precise phase composition and microstructure remains a challenge, primarily due to the necessity of scaffold sintering. This study addresses the challenges in developing customized patient-specific bone substitutes by proposing a sequential approach that reduces processing steps while providing control over the phase and morphology of the scaffolds' structure. The methodology utilizes freeze-casting and sintering for highly porous the scaffolds' preparation, followed by hydrothermal treatment to modify the microstructure. The introduction of CaCO3 induces a phase transformation of tricalcium phosphate, increasing the hydroxyapatite content, while the overall macrostructure retains the characteristics of freeze-casting. The surface morphology undergoes a transition from equiaxial grains to whiskers-like structures and hexagonal rods, impacting compressive strength. Following hydrothermal treatment, the formation of whiskers-like hydroxyapatite grains leads to a notable strength increase from 2.8 to 5.7 MPa. Remarkably, the scaffolds undergo nearly complete phase transformation, shifting from 100% tricalcium phosphate to 99% hydroxyapatite, all while conserving the macrostructure. Scaffolds with enhanced porosity and altered surface morphologies were created through freeze-casting, sintering, and subsequent hydrothermal treatment. The modified scaffolds maintained their overall macrostructure, displaying high porosity (>= 60%), diverse hydroxyapatite phase ratios (0-99%), and a compressive strength of 5.7 MPa. This study introduces a novel approach employing hydrothermal treatment for microstructural and phase customization of sintered scaffolds. image

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20504 - Ceramics

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF THE AMERICAN CERAMIC SOCIETY

ISSN

0002-7820

e-ISSN

1551-2916

Volume of the periodical

107

Issue of the periodical within the volume

12

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

7994-8006

UT code for WoS article

001285647400001

EID of the result in the Scopus database

2-s2.0-85200509561