STRENGTH DEGRADATION OF CALCIUM PHOSPHATE SCAFFOLDS UNDER CONDITIONS SIMULATING OSTEOCLASTIC RESORPTION

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F18%3APU130202" target="_blank" >RIV/00216305:26620/18:PU130202 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
STRENGTH DEGRADATION OF CALCIUM PHOSPHATE SCAFFOLDS UNDER CONDITIONS SIMULATING OSTEOCLASTIC RESORPTION
Original language description
Calcium phosphates (CaPs) ceramics are the first-choice material for large bone defect healing. Scaffolds prepared from CaPs must fulfill many demands. One of these demands is bioresorbability of the scaffold material. In case of sintered ceramic scaffolds the only degradation mechanism (at least at the beginning of the resorption) is acidic mechanism mediated by osteoclasts. This degradation leads inevitably to the loss of mechanical strength. The loss of mechanical strength should be continual and match the growth of the new bone tissue. Within the scope of our research we present results of the mechanical strength degradation of the three types of highly porous CaPs scaffolds. Hydroxyapatite (HA), tricalcium phosphate (TCP) and biphasic calcium phosphate (BCP) scaffolds with similar porosity (over 80%) and pore size were tested. Samples were exposed to slightly acidic environment of the McIlvaine buffer (pH 5.5) at a temperature of 37 °C. Strength degradation, phase and morphological changes were
Czech name
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Czech description
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Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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