Influence of ceramic particles on bioactivity of the ceramic-polymer biocomposites

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F18%3APU130584" target="_blank" >RIV/00216305:26620/18:PU130584 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Influence of ceramic particles on bioactivity of the ceramic-polymer biocomposites

Original language description

Ceramic-polymer nanofibers were prepared by the electrospinning method with the aim to prepare a biocompatible and bioactive structure usable as scaffold. Hydroxyapatite nanoparticles were chosen as the ceramic fillers of the polymer fibers composed of the polycaprolactone. The diameter of the prepared fibers was approximately 180 nm. The hydroxyapatite nanoparticles had needle-like shape. The needles were approximately 30 nm in the diameter and 300 nm long. Thanks to theirshape, they were easy to be incorporated into structure of the fibers. Dispersion of the particles in the solution was improved by plasma and ultrasound treatment ofthe precursor. Cytotoxicity tests were performed on the prepared fibers. Specific growth rate (proliferation rate of the cells) was evaluated on the samples. The results were compared with the results of baseline samples (slide glass) and polycaprolactone samples. It was found out that presence of the ceramic compound supports activity of the cells. Another improvement of the specific growth rate was reached by low-temperature plasma treatment of the fibers. Since standardized cytotoxicity testing is executed on the thinlayer of the material which is transparent for visible light, it was important to test “bulk” structure. The bulk structure simulates future utilization of the material as scaffolds. Therefore, thick layer of plasma-treated composite structure and polycaprolactone multi-layered fibrous structures as well as untreated polycaprolactone structure were tested. It was found out that that plasma treatment and ceramic particles in the structure have a great impact on the proliferation rate of the cells.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

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OECD FORD branch

20505 - Composites (including laminates, reinforced plastics, cermets, combined natural and synthetic fibre fabrics; filled composites)

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Proceedings of the workshop for young ceramists

ISBN

978-88-7586-599-3

ISSN

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e-ISSN

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Number of pages

146

Pages from-to

53-56

Publisher name

Editrice La Mandragora s.r.l

Place of publication

Bologna, Italy

Event location

Bologna

Event date

Nov 26, 2018

Type of event by nationality

EUR - Evropská akce

UT code for WoS article

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