Electrospinning and biocompatibility of polymer-ceramic nanofibers for tissue engineering

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F19%3APU130601" target="_blank" >RIV/00216305:26620/19:PU130601 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/18:PU130601
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Electrospinning and biocompatibility of polymer-ceramic nanofibers for tissue engineering
Original language description
Polycaprolactone is known as biocompatible material for long time and it is considered as possible material for bioscaffolds. Since natural structure of hard tissues (bones) and most of soft tissues (skin, neural tissue) is fibrous, there are attempts to mimic such a structure. Polycaprolactone (PCL) nanofibers with diameter of approximately 180 nm were prepared by electrospinning method. For better biocompatibility and bioactivity, a composite fibrous structure was prepared. Hydroxyapatite nanoparticles were synthetized via precipitation reaction and further hydrothermal treatment. The ceramic particles were added to modified polycaprolactone precursor and the solution was electrospun. The prepared fibers and as well as dried original precursor were in-vitro tested for cytotoxicity by direct contact test. Mouse fibroblast from L929 line were used for cell cultivation. It was found out that fibrous structure and presence of ceramic particles have a positive influence on cell activity and proliferation – the growth rate of the cells was significantly higher compared to bulk polymer precursor.
Czech name
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Czech description
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Project
<a href="/en/project/LM2015041" target="_blank" >LM2015041: CEITEC Nano</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
10TH ANNIVERSARY INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION (NANOCON 2018 (R))
ISBN
978-80-87294-89-5
ISSN
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e-ISSN
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Number of pages
5
Pages from-to
472-476
Publisher name
Neuveden
Place of publication
Neuveden
Event location
Brno
Event date
Oct 17, 2018
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000513131900082

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