Deficiency of Sprouty Proteins in Mice Resemble Ciliopathic Phenotype
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F19%3APU132816" target="_blank" >RIV/00216305:26620/19:PU132816 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/19:00112474
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/jmor.21003" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1002/jmor.21003</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Deficiency of Sprouty Proteins in Mice Resemble Ciliopathic Phenotype
Original language description
The Sprouty family of proteins is a highly conserved group of intracellular modulators of receptor tyrosine kinase signaling, including the fibroblast growth factor receptor (FGFR) pathway. There are four orthologs (Sprouty1-4) in mammals. During embryonic development and postnatal bone remodeling, tight regulation of FGFR signaling is essential in endochondral ossification and in bone and mineral homeostasis. Sprouty2 was shown to be implicated in endochondral bone formation in Sprouty2-/- mice with reduced postnatal skeletal size and trabecular bone mass. Nevertheless, the underlying mechanism of its action at the molecular level remains to be elucidated. Moreover, long bones of Sprouty4-/- display limb malformations, such as chondroma-like lesions in locations adjacent to growth plate, or fused and/or supernumerary digits on front limbs. Our skeletal and other phenotypic findings on Sprouty2- and 4-deficient mice and Sprouty2/4 double knockouts (DKOs) strikingly resemble the phenotype of model mice
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
10605 - Developmental biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů