Non-apoptotic functions of caspase-7 during osteogenesis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F14%3A00434299" target="_blank" >RIV/67985904:_____/14:00434299 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16170/14:43872986

Result on the web

<a href="http://dx.doi.org/10.1038/cddis.2014.330" target="_blank" >http://dx.doi.org/10.1038/cddis.2014.330</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/cddis.2014.330" target="_blank" >10.1038/cddis.2014.330</a>

Result language

angličtina

Original language name

Non-apoptotic functions of caspase-7 during osteogenesis

Original language description

Caspase-3 and -7 are generally known for their central role in the execution of apoptosis. However, their function is not limited to apoptosis and under specific conditions activation has been linked to proliferation or differentiation of specialised cell types. In the present study, we followed the localisation of the activated form of caspase-7 during intramembranous (alveolar and mandibular bones) and endochondral (long bones of limbs) ossification in mice. In both bone types, the activated form of caspase-7 was detected from the beginning of ossification during embryonic development and persisted postnatally. The bone status was investigated by microCT in both wild-type and caspase-7-deficient adult mice. Intramembranous bone in mutant mice displayed a statistically significant decrease in volume while the mineral density was not altered. Conversely, endochondral bone showed constant volume but a significant decrease in mineral density in caspase-7 knock-out mice. Cleaved caspase-7

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EA - Morphology and cytology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cell Death & Disease

ISSN

2041-4889

e-ISSN

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Volume of the periodical

5

Issue of the periodical within the volume

e1366

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

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UT code for WoS article

000341639000007

EID of the result in the Scopus database

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