Caspase-7 participates in differentiation of cells forming dental hard tissues

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F13%3A00397909" target="_blank" >RIV/67985904:_____/13:00397909 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16170/13:43871764
Result on the web
<a href="http://dx.doi.org/10.1111/dgd.12066" target="_blank" >http://dx.doi.org/10.1111/dgd.12066</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/dgd.12066" target="_blank" >10.1111/dgd.12066</a>

Result language
angličtina
Original language name
Caspase-7 participates in differentiation of cells forming dental hard tissues
Original language description
Apoptosis during tooth development appears dependent on the apoptotic executioner caspase-3, but not caspase-7. Instead, activated caspase-7 has been found in differentiated odontoblasts and ameloblasts, where it does not correlate with apoptosis. To further investigate these findings, the mouse incisor was used as a model. Analysis of caspase-7-deficient mice revealed a significant thinner layer of hard tissue in the adult incisor. Micro computed tomography scan confirmed this decrease in mineralized tissues. These data strongly suggest that caspase-7 might be directly involved in functional cell differentiation and regulation of the mineralization of dental matrices.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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