MicroCT analysis of caspase-7 deficient mice revealed impaired osteogenesis.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F14%3A43873325" target="_blank" >RIV/62157124:16170/14:43873325 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
MicroCT analysis of caspase-7 deficient mice revealed impaired osteogenesis.
Original language description
Caspase-7 belongs to executive apoptotic and pro-inflammatory caspases. Recent reports point to novel roles of these caspases, particularly in cell differentiation. As we revealed such function of caspase-7 in odontogenesis, we turned our attention to participation of this molecule in formation of hard tissue in general. In this work, both types of bones; intramembranous (mandibular/alveolar bone), and endochondral (long bones) were investigated. The microCT results confirmed a specific role of caspase-7 in osteogenesis. The different consequence of caspase-7 deficiency in the intramembranous vs endochondral bones corresponds to previously reported specificities in both types of ossification related to the expression patterns of periostin, BMPs or variations in the vascularisation.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
GJ - Diseases and animal vermin, veterinary medicine
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP502%2F12%2F1285" target="_blank" >GAP502/12/1285: Apoptotic and non-apoptotic functions of caspases in hard tissue formation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů