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MicroCT analysis of caspase-7 deficient mice revealed impaired osteogenesis.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F14%3A43873325" target="_blank" >RIV/62157124:16170/14:43873325 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    MicroCT analysis of caspase-7 deficient mice revealed impaired osteogenesis.

  • Original language description

    Caspase-7 belongs to executive apoptotic and pro-inflammatory caspases. Recent reports point to novel roles of these caspases, particularly in cell differentiation. As we revealed such function of caspase-7 in odontogenesis, we turned our attention to participation of this molecule in formation of hard tissue in general. In this work, both types of bones; intramembranous (mandibular/alveolar bone), and endochondral (long bones) were investigated. The microCT results confirmed a specific role of caspase-7 in osteogenesis. The different consequence of caspase-7 deficiency in the intramembranous vs endochondral bones corresponds to previously reported specificities in both types of ossification related to the expression patterns of periostin, BMPs or variations in the vascularisation.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

    GJ - Diseases and animal vermin, veterinary medicine

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GAP502%2F12%2F1285" target="_blank" >GAP502/12/1285: Apoptotic and non-apoptotic functions of caspases in hard tissue formation</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů