Differences in siRNA encapsulation between HsaHFt-RK ferritin and EcaLHFt

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F19%3APU134911" target="_blank" >RIV/00216305:26620/19:PU134911 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/19:43917123
Result on the web
<a href="https://mendelnet.cz/artkey/mnt-201901-0110_Differences-in-siRNA-encapsulation-between-HsaHFt-RK-ferritin-and-EcaLHFt.php?back=/magno/mnt/2019/mn1.php?secid=4" target="_blank" >https://mendelnet.cz/artkey/mnt-201901-0110_Differences-in-siRNA-encapsulation-between-HsaHFt-RK-ferritin-and-EcaLHFt.php?back=/magno/mnt/2019/mn1.php?secid=4</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Differences in siRNA encapsulation between HsaHFt-RK ferritin and EcaLHFt
Original language description
Nanomedicine in cancer treatment has a great potential. With usage of proper nanocarrier we would be able to eliminate negative side effects and excessively high toxicity of chemotherapeutical drugs to normal cells. Ferritins in general are proteins which could do the trick. Their ability to change structure in low pH could be used for drug delivery. Ferritins are also ubiquitous so there is also very small chance of immune reaction in body. First and the most used and described ferritin is EcaLHFt (ferritin from horse spleen). Its ability to encapsulate various molecules is already known and used in research laboratories. Only molecules with negative charge are troublesome to encapsulate into EcaLHFt. For this reason, we created recombinant human ferritin – HsaHFt-RK, which is designed to encapsulate predominantly negatively charged molecules. We were able to confirm this hypothesis by comparing the encapsulation efficiency of FAM-siRNA inside EcaLHFt and HsaHFt-RK.
Czech name
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Czech description
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Project
<a href="/en/project/GA17-12816S" target="_blank" >GA17-12816S: Construction of modified apoferritin nanocarriers bearing anticancer drugs and study of mechanisms enhancing their efficiency in anticancer therapy</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
MendelNet 2019 Proceedings of 26th International PhD Students Conference
ISBN
978-80-7509-688-3
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
551-556
Publisher name
Mendel University in Brno
Place of publication
Neuveden
Event location
Brno
Event date
Nov 6, 2019
Type of event by nationality
CST - Celostátní akce
UT code for WoS article
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