Possitively charged ferritin nanocages can deliver sirna into cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F20%3APU139200" target="_blank" >RIV/00216305:26620/20:PU139200 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.11159/icnfa20.122" target="_blank" >http://dx.doi.org/10.11159/icnfa20.122</a>
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Possitively charged ferritin nanocages can deliver sirna into cells
Original language description
Nanomedicine is based on using nanotransporters for transfer of drugs and other active compounds inside cancer tissue without damaging the normal cells and organs [1]. For this purpose, various types of molecules can be used. Using proteins as nanocarriers is tested for their biocompatibility, safety and non-toxicity [2]. Interested protein based nanotransporter is ferritin. It is ubiquitous, with convenient size, robust, stable at various conditions and it is easy to modify its surface to achieve active targeting [3]. However, its best quality is the ability to open the protein cage in pH below 3 and folding it back together in pH above 7 [4]. This property is used for active encapsulation of various molecules. By mixing ferritin with the compounds of interest, lowering pH with HCl and then returning pH back to neutral by addition of NaOH, we can encapsulated cargo inside ferritin cage [5]. Recombinant human ferritin (HsaFtH-RK) was designed and cloned under supervision of Dr. Pekarik. The production
Czech name
—
Czech description
—

Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)